Senior/Principal Scientist, Pipeline Development

Senior/Principal Scientist, Pipeline Development

South San Francisco, CA

The Company

Link Cell Therapies is developing a best-in-class logic-gate technology to spur a new generation of cell therapies for patients with solid tumors. Link’s “AND” gates require two cancer-associated targets for a CAR T cell to attack cancer cells, thereby providing specificity for killing of tumor cells while sparing healthy tissue. Combined with additional technologies under development, Link will advance a suite of exciting internal therapeutic programs while exploring opportunities for value creation with strategic partners.

Job Description

Link Cell Therapies is looking for a highly motivated Senior/Principal Scientist to join our Cell Therapy team and support the preclinical progression of anti-solid tumor programs within our development pipeline. Reporting to the VP of Cell Therapy, the successful applicant will collaborate effectively with other scientists and be responsible for carrying out

in vitro

studies that enable the nomination of development candidates. Furthermore, the candidate will also be expected to be a key contributor in IND-enabling experiments and activities. This is an opportunity to join an exciting new company during the discovery phase and to follow our programs throughout research pipeline advancement and into clinical studies.

Responsibilities

• Contribute hands-on and supervise a team of junior scientists in activities involving early discovery, lead optimization and IND-enabling studies for pipeline programs
• Contribute to the conception and design of

in vivo

studies to evaluate the efficacy and safety LINK CARs

• Generate data packages that follow strong research principles and enable pipeline decisions
• Present findings to stakeholders and company leadership
• Maintain an updated electronic laboratory notebook

Required Qualifications

• PhD in a relevant life sciences field with extensive (5-10 years for Senior, 10\+ years for Principal)

industry experience in CAR construct design and in the development of autologous Cell Therapies

• Demonstrated experience supporting cell therapy programs through early discovery and into IND-enabling stages
• Hands-on experience working with human T cells (isolation, culture, transduction, and expansion), T cell characterization assays (phenotyping, cytotoxicity, cytokine secretion) and multicolor Flow Cytometry (acquisition and analysis)
• Experience managing and mentoring junior scientists
• Self-motivator with strong organizational skills and a willingness to learn
• Fluency with Microsoft Office, GraphPad Prism and FlowJo

This is a hands-on, lab-based and on-site position based in South San Francisco, CA.

The salary range for this position is

$150,000 to 185,000 USD

annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.

In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.