Research Scientist 4

Duties Description

The New York State Institute for Basic Research is dedicated to understanding the causes of and possible treatments for a broad spectrum of developmental disabilities. IBR is presently recruiting for a Research Scientist 4 to join our Institute and ensure successful transition planning in our Mass Spectrometry Laboratory, which is part of the Centralized Services division, supporting the research work on our diverse research scientist profile. NYS OPWDD IBR provides a professional setting in a world-renowned research facility located on Staten Island, NY, on a wooded, suburban campus with free off-street parking. Attendance at and participation in professional meetings and conferences is encouraged and financially supported, and publication fees in professional journals are supported through the agency budget. Telecommuting work plan is negotiable after some probation period.

The Laboratory of Molecular Structure and Function provides mass spectrometric (MS) analyses to collaborating principal investigators at the Institute with the primary focus on proteomic analysis of mouse models of disease. The MS laboratory occupies a 460 sq. ft. laboratory with adjacent office spaces and is currently equipped with a Waters Xevo G2-XS tandem mass spectrometer interfaced with a 3-pump M-Class ACQUITY™ UPLC system via a nanoflow electrosprayer with a lock mass attachment. The system uses 1D or online 2D separation methods (SCX-RP or RP-RP) to separate peptides for analysis primarily by MSe functions provided in the MassLynx 4\.2 software suite. Proteomics data are processed using the ProteinLynx 3\.0\.3 and Progenesis QIP software suites as well as the MassLnyx 4\.2 suite. Data are collected initially on a Lenovo ThinkStation P720 computer workstation and processed on a separate Lenovo ThinkStation P720\. Long-term data storage is on dual mirrored Synology DS420\+ servers with current capacity of 20\.9 TB with backup to USB drives.

Current research projects underway include but are not limited to: We are using a MS proteomic approach to characterize a range of transgenic mouse models of Ogden Syndrome (OS), which in humans shows diverse pathological features including infant lethality. OS is caused by an X-linked mutation in the NAA10 gene that codes for the catalytic subunit of an N-terminal acetyltransferase (NatA). Our goal is to understand the roles that the Naa10 gene and NatA play in mouse development from the loss of NatA activity through the divergent pathways that lead to embryonic death.

Ultimately, in this position, the incumbent will direct collaborative research projects using high-resolution UPLC-mass spectrometry.

PRIMARY RESPONSIBILITIES:

• Ability to successfully operate a UPLC (ultra performance liquid chromatography) mass spectrometry (UPLC-MS) system
• Facilitate successful data extraction for analysis and engage in productive interpretation of findings
• Maintain and expand custom database, demonstrate experience running queries and display a working knowledge of SQL (structured query language)
• Support maintenance of data structure, server access and data backup of systems
• Collaborate with laboratory scientists and principal investigators on multi-disciplinary projects
• Facilitate and maintain good communication with collaborators
• Display and engage in scientific curiosity to develop future research questions and collaboration opportunities

Preferred Qualifications: Ph.D. in biochemistry, chemistry, molecular biology or related field and laboratory experience with high resolution mass spectrometry, preferably with proteomic or biomolecular samples. Facility with computers and software, including an understanding of bioinformatics approaches, databases and Excel spreadsheets. Programming experience is beneficial.

https://www.linkedin.com/company/nys-office-for-people-with-developmental-disabilities/posts/?feedView\=all

Minimum Qualifications

Non-Competitive:

Bachelor’s degree and five years of professional research experience in an appropriate field.

Substitutions:

Master’s degree in an appropriate field may substitute for one year of experience, and Ph.D. in an appropriate field may substitute for an additional year of experience.

Additional Comments

• Please note that starting salary for this title reflects the Downstate adjustment. Posted Hiring Salary includes the sum of the statutory hiring rate for PS\&T Grade 27 ($106,898) and Downstate adjustment ($4,000). Downstate adjustment is added to the job rate ($131,665).
• The assignment of PS\&T employees will be made in accordance with any agreed upon Memorandum of Understanding between PEF and the local DDSO regarding the posting of job vacancies.
• Preference will be given to OPWDD employees impacted by closures. If you are being impacted by closure, please indicate this on your resume.
• All OPWDD employees must be eligible and maintain eligibility for full and unconditional participation in the Medicare and Medicaid programs. Continued employment will depend on maintaining eligibility.
• If you are employed by state government you may be able to receive loan forgiveness under the Public Service Loan Forgiveness Program (PSLF). The PSLF Program forgives the remaining balance on Direct Loans after 120 qualifying monthly payments have been made under a qualifying repayment plan while working full-time for a qualifying employer. For more information on PSLF, please visit www.studentAid.gov/publicservice.
• Employees on long term leave can bid on positions but must be able to report to work within fourteen (14) days and be able to perform the essential functions of their positions with or without reasonable accommodation (RA).
• If an employee or job applicant believes that they need a reasonable accommodation, they should contact the Reasonable Accommodation Unit at (518) 486-7222 or email accommodationrequests@opwdd.ny.gov to obtain information and RA forms.
• Savings programs such as the U.S. Savings Bond and the College Savings Plan.
• Voluntary pre-tax savings programs such as Health Care Spending Account and the Dependent Care Advantage Account offer employees options to pay for uncovered health care expenses or dependent care expenses.
• Access to the Employee Assistance Program (EAP) an assessment and referral service that connects employees with local service providers and support services to address their personal needs.
• Life insurance and Disability insurance.
• The New York State Deferred Compensation Plan is a voluntary retirement plan that offers employees the option to invest a part of their salaries for retirement on a tax-deferred basis.
• Paid Holidays and Leave:

° Thirteen (13) paid holidays each year.

° Thirteen (13) days of paid vacation leave initially.

° Five (5) days paid personal leave each year.

° Thirteen (13) days of paid sick leave each year (PEF/CSEA), which may carry over from year to year.

° Up to three (3) days professional leave each year to participate in professional development events.

• Health Care Coverage:

Employees and their eligible dependents can choose from a variety of affordable health insurance programs. Employees are provided family dental and vision plans at no extra cost.

• Paid Parental Leave:

Paid Parental Leave allows eligible employees to take up to 12 weeks of paid leave at full pay for each qualifying event. A qualifying event is defined as the birth of a child or placement of a child for adoption or foster care.

• Retirement Program:

Participate in The NYS Employees’ Retirement System (ERS), which is recognized as one of the best-managed and best-funded public retirement systems in the nation.

• Professional Development and Education and Training:

NYS offers training programs and tuition assistance to eligible employees to maintain and increase their professional skills and prepare them for promotional opportunities. For more information, please visithttps://oer.ny.gov/training-and-professional-development.

• Additionally, the Public Service Workshops Program (PSWP) offers certain professional training opportunities for PEF represented and M/C designated employees that may grant continuing education credits towards maintaining professional licensure. For more information, please visit https://oer.ny.gov/public-service-workshops-program-pswp.
• OPWDD is an Equal Opportunity/Affirmative Action employer dedicated to creating and sustaining a culture of inclusion. We believe that we are most effective in managing and improving our service system with a diverse team of employees. With such a large workforce, we rely on the collective individual differences, life experiences, knowledge, self-expression, ideas and talent that our employees bring to their work. This speaks to our culture and is a key part of our successes. As we continuously recruit people for our team, we welcome the unique contributions that applicants bring in terms of their education, culture, ethnicity, race, sex, gender identity and expression, nation of origin, age, languages spoken, veteran’s status, color, religion, disability, sexual orientation and beliefs.

All people with disabilities are encouraged to apply.