Senior Scientist, Immunology

Senior Scientist, Immunology

Location:

Redwood City, CA

About Hinge Bio, Inc.

Hinge Bio, Inc. is a privately-held biotechnology company leveraging its powerful GEM‑DIMER™ platform to develop therapeutics that address the problems of resistance, inadequate efficacy, and side effects in the fields of immune-mediated disease, and cancer. The GEM-DIMER™ platform enables the creation of multivalent, multi-specific antibody-based therapeutics that are designed for enhanced biological activity and unique functionality.

GEM-DIMER™ technology uniquely enables modular design, efficient manufacturing, and precise targeting for a variety of target product profiles and has demonstrated encouraging preclinical efficacy and safety across multiple therapeutic programs.

Position Summary

Hinge Bio is seeking a creative and accomplished scientist to support discovery and advancement of immunotherapy candidates to IND-filings for autoimmune diseases and oncology. The position provides the opportunity to join a creative, energetic and innovative research and development team. This is a “hands on” role reporting to the Associate Director of Immunology and is expected to contribute to all aspects of the programs from early discovery to development.

This is an on-site position based at Hinge Bio’s labs and offices in Redwood City, CA.

Key responsibilities

·     Lead the design, execution, and interpretation of in vitro and ex vivo studies to characterize the mechanism, potency, and biological activity of GEM-DIMER™ therapeutic candidates.

·     Serve as the immunology lead for one or more discovery-stage programs, providing scientific direction and driving progression from target validation through candidate selection.

·     Develop innovative functional assays using primary human immune cells and disease-relevant systems

·     Collaborate with protein engineering, translational biology, and external partners to advance therapeutic candidates.

·     Design and oversee studies conducted at CROs.

·     Generate scientific insights that influence program strategy, lead optimization, and preclinical development.

·     Present findings and recommendations to project teams and research leadership.

·     Prepare scientific reports, publications, patents, and regulatory documents supporting IND-enabling activities.

·     Support advancement of the GEM-DIMER™ platform and foster scientific excellence within the team.

Required qualifications

·     Ph.D. in Immunology, Cell Biology, Molecular Biology, Biochemistry, or a related field with 4\+ years of biotechnology or pharmaceutical industry experience; or M.S. with 8\+ years of relevant industry experience.

·     Demonstrated experience contributing to therapeutic discovery programs and advancing candidates through key preclinical milestones.

·     Strong background in immunology and experience developing and applying cellular assays to support biologics or antibody therapeutics.

·     Hands-on expertise with primary human immune cells, multiparameter flow cytometry, cell-based functional assays

·     Proficient developing immunoassays by ELISA, MSD/Luminex, Incucyte, and/or other technology platforms.

·     Experience interpreting complex biological datasets and translating findings into actionable program recommendations.

·     Ability to independently lead projects while working effectively in a collaborative, cross-functional environment.

·     Strong written and verbal communication skills with experience presenting to senior scientific leadership

Bonus Experience

·     Autoimmune disease, inflammation, immuno-oncology, oncology, or infectious disease research

·     Multi-specific antibodies, antibody engineering, or other next-generation biologics

·     IND-enabling, including MoA, target engagement, receptor occupancy, PK/PD, efficacy, or safety studies

·     Familiarity with regulatory documentation and study reports supporting IND submissions

·     Advanced approaches such as spectral flow, HTS/automation, live-cell imaging, single-cell RNA-seq, transcriptomics, CRISPR/functional genomics, or high-dimensional immune profiling

·     In-vivo pharmacology or translational biomarkers

Why Hinge Bio

At Hinge Bio, you will help shape the development of innovative therapies as a visible member of a highly collaborative team. Patients are at the center of everything we do, and we pursue transformative medicines for serious diseases with urgency, integrity, and rigor. Through successes and setbacks, we persevere together, drawing on our unique experiences and collective expertise to make a real difference in patients’ lives.

Hinge Bio is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.