Sr Computational Biologist

About The Job

The Senior Scientist, Cancer Genomics position sits within the Research \& Early Development team in the Product Development group and is responsible for leading discovery projects to establish correlations between genotype and phenotype. Using a variety of phenotypic measures, the role supports the discovery of novel biomarkers, drug sensitivity, resistance signatures, and genomic alterations involved in tumorigenesis. The primary functions rely on leveraging FoundationCORE, FMI’s 300,000\+ tumor sample dataset, to investigate novel cancer gene alterations (including annotation using publicly-available online resources such as UniProt and The Cancer Genome Atlas Program) and prepare scientific manuscripts.

Key Responsibilities

• Develop and evaluate potential biomarkers using FoundationCORE.
• Determine when statistical analysis is needed and apply the analysis.
• Use a computer cluster to analyze genomic signatures on historical samples.
• Communicate with Biopharma partners and internal departments as needed to define specifics of cancer mutations and other related scientific queries.
• Perform queries for Biopharma partners and return results.
• Utilize cancer genomics expertise to investigate genomic mechanisms of oncogenesis.
• Integrate appropriate clinical data with Next-Generation Sequencing (NGS) output.
• Collaborate with clinical partners in genomic-focused translational research projects that result in abstracts and publications.
• Contribute scientific expertise to broader projects within the Research and Development team.
• Other duties as assigned.

Qualifications

Basic Qualifications:

• PhD in a life science or mathematical field with a clinical focus
• 3\+ years of industry or post-doctorate experience within Cancer Biology, Bioinformatics, Biochemistry, or another related life science
• 1\+ years of industry or post-doctorate experience with cancer genomics and next-generation sequencing principles
• Proficiency with one or more of the following scientific computing languages: Python, R, Matlab, or Java

Preferred Qualifications

• Practical graduate and post-doctoral experience exhibited by first-author publications
• Working knowledge of clinical nomenclature including stage, grade, ECOG, and the patient journey in oncology
• Experience managing collaborations with multiple stakeholders
• Experience mentoring and developing less experienced scientists
• Ability to analyze and critically interpret scientific literature
• Exceptional reliability, high ethical standards and integrity
• Translational research experience
• Understanding of HIPAA and the importance of patient data privacy
• Commitment to reflect FMI's values: Integrity, Courage, and Passion

The expected salary range for this position based on the primary location of Boston, MA is $145,000 - $180,000 per year. The salary range is commensurate with FMI’s compensation practice and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for FMI benefits.